Efficacite d’un dispositif medical a base d’acide hyaluronique liposome contre la secheresse vulvo-vaginale

J.-M.BohbotC.de BeIllovskyG.BramiP.Maresc

Abstract

Objectives

Hyaluronic acid (HA) is present in the vulva) and vaginal conjonctive tissue. It possesses hydrating and healing properties and is indicated to treat menopause induced vulvo-vaginal atrophy. The goal of this study is to evaluate the efficacy of a medical device based on HA upon patients of different ages suffering from vulvo-vaginal dryness (VVD).

Methods

Tested product based on HA was applied 3 times a week for 84 days by 47 patients,

28 premenopausal young women (mean age: 32 years old) and 19 post-menopausal women (mean age: 57.5 years old) all suffering from VVD associated to spontaneous pain and dyspareunia. Clinical evaluations and Vaginal Health Index (VHS) were calculated at 0, 1 and 3 months.

Results

A significant clinical improvement (P < 0.001) occurred at 1 month (-25 % for dryness and —46 % for pain) and at 3 months (respectively —86 and —79 %). VHS was significantly improved (P < 0.001) from 30 % at 1 month to 72 % after 3 months.

Conclusion

Gel based on HA significantly decreases symptoms and clinical signs of VVD at all ages and represents a safe and efficient alternative to topical and/or systemic hormonal therapy after menopause.